The results of the current study demonstrate the feasibility of CoA-OCV for use in future OCT-V studies. In rabbit corneas, resonance frequencies of 360–460 Hz were observed. Only thickness and E contributed to the variance of FWHM. Full width at half maximum (FWHM) of the resonance modes increased with increasing thickness and decreased with increasing E. E showed the most predominant impact in the shift of the resonance frequencies. Resonance frequencies increased with thickness at a rate of 0.25 Hz/µm for E = 0.3 MPa, and 0.40 Hz/µm for E = 0.16 MPa. For E = 0.3 MPa, resonance frequencies increased with IOP at a rate of 3.9, 3.7 and 3.5 Hz/mmHg for varied thicknesses and 1.7, 2.5 and 2.8 Hz/mmHg for E = 0.16 MPa. Resonance frequencies of corneal phantoms were measured at varying intraocular pressures (IOP), and dependencies on Young´s Modulus (E), phantom thickness and IOP were observed. Sample vibrations were measured via phase-sensitive swept-source optical coherence tomography (OCT). Sample vibrations were stimulated via a loudspeaker, and pre-compensation was used to calibrate the acoustic spectrum. We present a co-axial acoustic-based optical coherence vibrometry probe (CoA-OCV) for vibro-acoustic resonance quantification in biological tissues.
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